Mechanism of Immune Privilege
نویسندگان
چکیده
The eye is a privileged site that cannot tolerate destructive inflammatory responses. Inflammatory cells entering the anterior chamber of the eye in response to viral infection underwent apoptosis that was dependent on Fas (CD95)-Fas ligand (FasL) and produced no tissue damage. In contrast, viral infection in gid mice, which lack functional FasL, resulted in an inflammation and invasion of ocular tissue without apoptosis. Fas-positive but not Fas-negative tumor cells were killed by apoptosis when placed within isolated anterior segments of the eyes of normal but not FasL-negative mice. FasL messenger RNA and protein were detectable in the eye. Thus, Fas-FasL interactions appear to be an important mechanism for the maintenance of immune privilege.
منابع مشابه
Immune Privilege
T he concept of immune privilege refers to the observation that tissue grafts placed in certain anatomical sites, including the brain and eye, can survive for extended periods of time (1). Immune privilege is thought to reflect an evolutionary adaptation to protect vital structures from damage by inflammatory responses directed against pathogens. It was originally believed that antigens in immu...
متن کاملOcular Immune Privilege and Transplantation
Allografts are afforded a level of protection from rejection within immune-privileged tissues. Immune-privileged tissues involve mechanisms that suppress inflammation and promote immune tolerance. There are anatomical features, soluble factors, membrane-associated proteins, and alternative antigen-presenting cells (APC) that contribute to allograft survival in the immune-privileged tissue. This...
متن کاملThe retinal pigment epithelial cells modulate phagolysosome activation in macrophages through neuropeptides, a-MSH and NPY
Objective: The main function of the human eye is to detect light, motion, and color from our surroundings. This information is then processed and translated in the brain as vision. However, what is less known about the eye is its ability to regulate immune function. It is this ocular immune privilege that maintains the eye’s ability collect visual information. The degeneration of immune privile...
متن کاملOcular Immune Privilege and Ocular Melanoma: Parallel Universes or Immunological Plagiarism?
Evidence of immune privilege in the eye was recorded almost 140 years ago, yet interest in immune privilege languished for almost a century. However, the past 35 years have witnessed a plethora of research and a rekindled interest in the mechanisms responsible for immune privilege in the anterior chamber of the eye. This research has demonstrated that multiple anatomical, structural, physiologi...
متن کاملRole of B7-H1 in immune privilege of the eye.
The normal eye possesses immunologic privilege. When grafted orthotopically to the eyes of experimental animals, allogeneic corneas enjoy a relatively high level of acceptance, compared with orthotopic grafts of other types of solid tissue. Even corneas grafted into eyes of preimmunized recipients are often not subject to immune rejection. To understand the molecular mechanisms of immune privil...
متن کاملStructural, cellular and molecular aspects of immune privilege in the testis
The testis presents a special immunological environment, considering its property of immune privilege that tolerates allo- and auto-antigens. Testicular immune privilege was once believed to be mainly based on the sequestration of antigens from the immune system by the blood-testis barrier in the seminiferous epithelium. Substantial evidence supports the view that the combination of physical st...
متن کامل